Research References

Baxyl® with MHB3 Hyaluronan is the most researched and proven joint relief supplement on the market. Baxyl is a completely hydrated, oral, liquid supplement which allows for quick absorption and maximum efficacy. Here are some of the research articles that indicate the efficacy of hyaluronan on joint health:

  • Al-Bayaty, F, et al. Evaluation of hyaluronate against gastric mucosa. African Journal of Pharmacy and Pharmacology. 5(1): 23-30 (2011).
  • Balogh, L et al. Absorption, Uptake and Tissue Affinity of High-Molecular-Weight Hyaluronan after Oral Administration in Rats and Dogs. J. Agric. Food Chem. 2008, 56, 10582?10593 (2008).
  • Bastow, E. et. al. Hyaluronan synthesis and degradation in cartilage and bone. Cellular and Molecular Life Sciences. 65, 395-413 (2008).
  • Fraser, J., Laurent, T., and Laurent, U. Hyaluronan: its nature, distribution, functions and turnover. Journal of Internal Medicine, 242, 27-33 (1997).
  • Gerdin, B. and Hallgren, R. Dynamic role of hyaluronan in connective tissue activation.. Journal of Internal Medicine. 242, 49-55 (1997).
  • Gong, H., Underhill, C. and Freddo, T. Hyaluronan in the bovine ocular anterior segment, with emphasis on the outflow pathways. Investigative Ophthalmology & Visual Science. 35, 4328-4332 (1994).
  • Hefner, CS (2012). Oral Hyaluronan Dosage Forms in the Management of Joints. Doctoral Dissertation. Global College of Natural Medicine, Santa Cruz, California. Print.
  • Juhlin, L. Hyaluronan in skin. Journal of Internal Medicine. 242, 61-66 (1997).
  • Kiburz, DW. Evaluation of MHB3® among Patients. Unpublished, (2006).
  • Lukens W. Unpublished data (2005).
  • Ma, J and EA Turley. Evaluation of MHB3® on Bone. (2008).
  • McDonald, J. and Camenisch, T. Hyaluronan: Genetic insights into the complex biology of a simple polysaccharide. Glycoconjugate Journal, 19, 331-339 (2002).
  • Meyer, K. and Chaffee, E. The mucopolysaccharides of skin. The Journal of Biological Chemistry. 138, 491-499 (1941).
  • Prince, C. Roles of hyaluronan in bone resorption. BMC Musculoskeletal Disorders. 5, 12 (2004).
  • Sabaratnam, S. et. al. Size selectivity of hyaluronan molecular sieving by extracellular matrix in rabbit synovial joints. The Journal of Physiology.567, 569-581 (2005).
  • Seog, J. Direct measurement of glycosaminoglycan intermolecular interactions via high-resolution force spectroscopy. Macromolecules. 35, 5601-5615 (2002).
  • Walker, P. et. al. Boosted lubrication in synovial joints by fluid entrapment and enrichment. Annals of the Rheumatic Diseases. 27, 512 (1968).
  • Wang, F. et. al. In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in human skin. Archives of Dermatology. 143, 155-163 (2007).
  • Weist, L. and Kerscher, M. Native hyaluronic acid in dermatology?results of an expert meeting. Journal of the German Society of Dermatology. 6, 176-180 (2008).